The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology
The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology book cover

The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology

Hardcover – February 15, 2022

Price
$18.30
Format
Hardcover
Pages
368
Publisher
PublicAffairs
Publication Date
ISBN-13
978-1541797918
Dimensions
6.4 x 1.55 x 9.6 inches
Weight
1.28 pounds

Description

“[A] fascinating survey of the present and future of biotechnology.”― Nature “[A] road map for navigating [synthetic biology’s] opportunities and perils.”― The New Yorker “The book is a brilliant narrative of the future of human life. Webb and Hessel explain the complex matter in such a way that experts and laypeople alike can follow, whose biology lessons were a while ago.”― Handelsblatt “[A] thought-provoking introduction to synthetic biology…[a] breathtaking science, but it is also scary. Who's in charge, and where are the brakes?”― Booklist “[D]eeply researched but accessible prose… A wrinkle on the near future that many readers will not have pondered—and should.”― Kirkus “ The Genesis Machine is a brilliant pairing of two visionaries who offer us a comprehensive take on making a better world through biology.”― Jane Metcalfe, cofounder of Wired and CEO of NEO.LIFE “ The Genesis Machine is a very readable story about how the DNA world is shifting from reading the genetic code to writing and editing it. Amy Webb and Andrew Hessel then take the reader on a journey of possible world changing events that could result from this new technology.”― J. Craig Venter, PhD, author of Life at the Speed of Life: From the Double Helix to the Dawn of Digital and CEO of JCVI “This spectacular and highly accessible book clearly and thoughtfully examines the most important revolution of our lives––and of life itself . Understanding how we and future generations will use the tools of synthetic biology to transform the worlds inside and around us is essential to being an informed and empowered person and citizen in the twenty-first century. The Genesis Machine is a guide to exactly that and a must-read book.”― Jamie Metzl, member of WHO expert committee on human genome editing and author of Hacking Darwin: Genetic Engineering and the Future of Humanity “You may not realize it yet, but your life—and all of life itself—is about to change. From programmable genes to designer medicines, synthetic biology is going to transform everything. The Genesis Machine is a surprisingly intimate, incisive, and readable guide to the opportunities, risks, and moral dilemmas ofxa0the brave new world ahead.”― Steven Strogatz, Cornell University, author of Infinite Powers “ The Genesis Machine is a tour de force! Amy Webb and Andrew Hessel masterfully reveal the emerging network of forces—people, labs, computer systems, government agencies, and businesses—that will drive humanity’s next great transformation. Their fascinating (and frightening) conclusions—that the human ecosystem can actually become programmed—will touch every facet of our lives in the future. This brilliant work is an absolute must-read for national security professionals and defense planners who need to understand the complex dynamics at play in the future competition for bio-hegemony.”― Dr. Jake Sotiriadis, chief futurist, United States Air Force “We can now program biological systems like we program computers, with artificial intelligence and machine learning accelerating the speed of innovation and applications of synthetic biology. In an accessible and fascinating narrative, The Genesis Machine lays out a roadmap for this interdisciplinary field of synthetic biology that is forever reshaping life as we know it.”― Rana el Kaliouby, author of Girl Decoded: A Scientist’s Quest to Reclaim Our Humanity by Bringing Emotional Intelligence to Technology and deputy CEO, Smart Eye “Are latest innovations in synthetic biology simply a miracle that ends a crisis or a breakthrough to an entirely new way of living? That’s the question futurist Amy Webb and microbiologist Andrew Hessel reveal for us with this fascinating book. The history of the world is a history of unintended consequences, for better and for worse, and Webb and Hessel capture the coming fusion of tech and biology in vivid detail.”― Ian Bremmer, author of Collision Course “ The Genesis Machine is fantastic, explaining how genetic code is the alphabet in which much of the future will be written. Amy Webb and Andrew Hessel have taken the very complicated subject of synthetic biology and made it understandable with sharp prose and sharp analysisxa0that cut through mysteries of science and twenty-first-century humanism.”― Alec Ross, author of The Industries of the Future and The Raging 2020s Amy Webb advises CEOs of the world’s most-admired companies, three-star admirals and generals, and the senior leadership of central banks and intergovernmental organizations on the future of technology and science.xa0Axa0quantitative futurist, Amy is the CEO of the Future Today Institute, a leading foresight and management consulting firm. She is a professor of strategic foresight at New York University's Stern School of Business and a Visiting Fellow at Oxford University's Säid School of Business. She was elected a life member of the Council on Foreign Relations, is a member of the Bretton Woods Committee and serves as a Steward and Steering Committee member of the World Economic Forum.xa0She was also a Delegate on the former U.S.-Russia Bilateral Presidential Commission, where she worked on the future of technology and international diplomacy.xa0Amy was named by Forbes as "one of the five women changing the world," honored as one of the BBC's 100 Women of 2020 and is ranked by Thinkers50 as one of the most influential business minds in the world. Amy is award-winning author of The Big Nine: How the Tech Titans and Their Thinking Machines Could Warp Humanity and The Signals are Talking: Why Today's Fringe is Tomorrow's Mainstream . Andrew Hessel , a pioneer and an expert in the field of synthetic biology, is the president of Humane Genomics, an early-stage company developing synthetic viruses for canine and human oncology. He is also the co-founder and chairman of the Center of Excellence for Engineering Biology and the Genome Project, the international scientific effort to engineer large genomes, including the human genome. He is a former distinguished research scientist at Autodesk Life Sciences.

Features & Highlights

  • Named one of The New Yorker's BEST BOOKS OF 2022 SO FAR
  • The next frontier in technology is inside our own bodies.
  • Synthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field—which uses computers to modify or rewrite genetic code—has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing.  It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel. But there are significant risks. Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event?  Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.

Customer Reviews

Rating Breakdown

★★★★★
60%
(126)
★★★★
25%
(53)
★★★
15%
(32)
★★
7%
(15)
-8%
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Most Helpful Reviews

✓ Verified Purchase

How global leaders can resolve the most serious economic, geopolitical, and social challenges

My undergraduate, graduate, and postgraduate studies have been limited almost entirely to the humanities. However, I have developed a serious interest in synthetic biology and am deeply grateful to Amy Webb and Andrew Hessel for making me feel welcome and (yes) valued while accompanying them during an exciting as well as informative journey of discovery.

As they explain, "The Genesis Machine incorporates many different biotechnologies [moving parts], all of which were created to edit and redesign life [in coordination and synchronization]. A series of new biological technologies and techniques, which broadly fall under synthetic biology's umbrella, will allow us not just to read and edit DNA code but to [begin italics] write it [end italics]. Which means that, soon, we will program living, biological structures as though they were tiny computers." (Page 5)

Webb and Hessell then add, "Life is becoming programmable, and synthetic biology makes a bold promise to improve human existence. Our purpose in this book is to help you think through the challenges and opportunities on the horizon. Within the next decade, we will need to make important decisions: whether to program novel viruses to fight diseases, what genetic privacy will look like, who will 'own' living organisms, how companies should earn revenue from engineered cells, and how to contain a synthetic organism in a lab."(Pages 6-7)

Note: Many of the central issues to be considered are suggested on Pages 8-9. For example, consider the first: "Those who can manipulate life can exert control over our food supply, medicines, and the raw materials required for our survival." The material in The Genesis Machine can help global leaders to resolve economic, geopolitical, and social tensions.

Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will obviously change -- in some instances disrupt -- our lives over the coming years, leading to cheaper drugs, "green" means by which to fuel our cars, and targeted therapies for attacking "superbugs' and diseases, such as cancer. The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.

These are among the dozens of passages of greatest interest and value to me, also listed to suggest the scope of Webb and Hessel's coverage:

o Introduction: Should Life Be a Game of Chance? (Pages 1-10)
o Recombinant DNA (19-20 and 248-252)
o The Factory of Life (22-26)
o Sequencing of genome (29-46)
o John Craig Venter (31-32, 35-43, 45-46, 106-107, and 147-149)

o George Church (69-77 and 75-80)
o Bioeconomy (95-99, 253-254, & 267-269)
o Biological Age (109-122 and 131-13e5)
o Genetically engineered organisms (GMOs) 124-125, 137-138, 155-156, 178-179, 182-183, and 186-187
o Risks associated with synthetic biology (137-141

o Chinese Communist Party (140-141
o Bioweapons/counterweapons (latter 142-143 and former 260-262)
o DYO kits for CRISPR (clustered regularly interspaced short palindromic repeats) 153-154 & 156-158
o Stifling of innovation (158-161)
o Golden Rice (170-!88)

o Halting of aging (177-181)
o Greenpeace (178-179, 182-183, and 185-186)
o Synthetic biology (205-213,
o Future of food culture (215-223)
o Colony Prize (227-236)

I agree with Amy Webb and Andrew Hessel: "If we can develop our thinking and strategy on synthetic biology today, we will be closer to solutions for the immediate and long-term existential challenges posed by climate change, global food insecurity, and human longevity." They keep the "bold promise" quoted earlier while making a contribution to global thought leadership of incalculable value. Bravo!

I highly other sources that have also been great interest to me, listed in chrono order:

The Selfish Gene
Richard Dawkins (1976)

The Gene: An Intimate History (2016)
Siddhartha Mukherjee

A Brief History of Everyone Who Ever Lived: The Human Story Retold Through Our Genes (2018)
Adam Rutherford

Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past (2019)
David Reich
14 people found this helpful
✓ Verified Purchase

A great insight into humanities next big era.

A surprisingly pleasant to read introduction to the world of synthetic biology. I especially like the scenarios and some very clever examples of what our future will be like as we enter this new age of humanity being able to program the genes of other creatures, and ourselves.
11 people found this helpful
✓ Verified Purchase

Wow. We'll be talking about this book for a long time.

This book is absolutely riveting. At first I was a little intimidated but once you start reading, The Genesis Machine will open your eyes up to the future and so many fascinating possibilities- and pitfalls. The authors help us see why this matters to us now, and how we can help use the concepts to be more pro-active about all of our futures. I can't wait for my friends and colleagues to read- so much to discuss and unpack!
4 people found this helpful
✓ Verified Purchase

Best book on the subject

I’ve read more books than I can count on the subject of synthetic biology. Many of them get lost in the science. This one is about the people behind the science, which makes the subject understandable, relatable, and so much easier to understand. This book gets it right.
3 people found this helpful
✓ Verified Purchase

Brilliant and timely

A wonderful deep dive into a technology and science that seems out of a sci-fi movie! If you enjoy reading about the latest technology, synbio, and scenarios of what the future might hold this is a must-read.
3 people found this helpful
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Clear near, medium and long term implications of a profound shift

While it might seem like a book about science--and synthetic biology is cutting-edge science, what sets Amy's book apart is its focus on how advances in this sphere will impact society and business. It has clear implications for business leaders, in particular, on how to think about what certainly lies ahead even if the timing with which some of these changes will manifest themselves can be debated. The writing is lucid and so are the potential "use cases" and applications.
1 people found this helpful
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History, conjecture and little science

After excitedly spending an Audible credit to buy the audiobook, listening to it at 1.2x speed for three hours, and having not learned anything, I wondered if I had misread the reviews. So I went back and looked at the Amazon reviews, including the critical ones this time. I sure wish I had done that before wasting a credit. The top critical review gets it right: nothing but history, a tiny bit of popular science, and conjectured simple “future” stories. I wasted a credit and time.

Public reviews have become almost worthless. More and more I am disappointed by “4.5 stars.” I learn more truth from the low-star reviews.
1 people found this helpful
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Great book that runs the gamut of synthetic biology

The term "natural" used to be substantially easier to apply to basic items like fruit and animals. It is both exhilarating and frightening to consider "improving" genetic material, but humans have a knack for putting their marks on everything imaginable.

"The Genesis Machine" by Amy Webb and Andrew Hessel takes on the Herculean effort (at breakneck speed) of categorizing, assessing and theorizing how synthetic biology is changing – and will change – the world. The book goes into just enough detail (and contains plenty of footnotes, if you want to dive further) about an array of topics, from CRISPR to artificial intelligence to vaccine creation (and hindrance).

The book's first three parts – past (thorough and grounded), present (eye-opening and dizzying) and future (a lot of good, albeit not necessarily all practical, what ifs) – outline the situation at hand. The final section details a list of recommendations and guidelines for how the world should proceed in this area.

It all sounds good on paper, but if we're being pragmatic about it, the rich and powerful will ultimately push forth agendas that will create an even more dramatic divide between them and their minions. This book is a great way to help organize the players and keep tabs on the highlights. And there's plenty of money to be made in this space, so let's hope that at least some of the breakthroughs keep the planet and humanity afloat.