The Song of the Cell: An Exploration of Medicine and the New Human
The Song of the Cell: An Exploration of Medicine and the New Human book cover

The Song of the Cell: An Exploration of Medicine and the New Human

Hardcover – October 25, 2022

Price
$17.89
Format
Hardcover
Pages
496
Publisher
Scribner
Publication Date
ISBN-13
978-1982117351
Dimensions
6 x 1.4 x 9 inches
Weight
1.68 pounds

Description

An Amazon Best Book of November 2022: Song of the Cell is a feat of storytelling. Siddhartha Mukherjee seamlessly pulls together personal anecdotes, little-known history (including a massive feud between two pancreatic experts with all the drama of Hamilton ), and the latest health research. We know words like "hormones" and "liver," but Mukherjee makes us truly understand how they function, and where they fit into our body as a whole. The name of the book describes how cells make the "symphony" of our body, all the disparate functions that work to keep us alive (and how they break down as we approach death). I even learned more about COVID, despite feeling like we’ve read it all. This is a book that deserves to be read slowly and thoughtfully, to revel in the awe of the human body that comes through in every word written by Mukherjee, also the Pulitzer-prize winning author of The Emperor of All Maladies: A Biography of Cancer , and a practicing physician and researcher. When it comes to the body, Mukherjee says: “We have learned so much. We have so much left to learn.” A philosophical take on the body, and life. —Lindsay Powers, Amazon Editor Praise for Song of the Cell “This expansive, immersive book posits a new way forward in medicine thanks to the cell: new ways of treating patients, new medicines to create, new ways of healing, and new ways of understanding ourselves.” — Jaime Rochelle Herndon, Columbia Magazine “In an account that’s both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes.” —The New Yorker "Erudite, panoramic… Mukherjee is an elegant stylist… [and] an assured and genial guide." —Hamilton Cain, Minneapolis Star-Tribune “If you are not already in awe of biology, The Song of the Cell might get you there. It is a masterclass.” —Suzanne O’Sullivan, The Guardian “Audacious...mesmerizing…reliably engaging... Mukherjee enthusiastically instructs and... delights—all the while hustling us across a preposterously vast and intricate landscape.” —David A Shaywitz, The Wall Street Journal “Mukherjee is a passionate, expert guide… He weaves together charming histories of scientists, his own, sometimes painful, memories of patients and friends lost to illness, and the complex science of what makes cells tick.” —Hannah Kuchler, The Financial Times “For anyone who wants to understand the building blocks of their own bodies—which everyone surely should—this is an informative and entertaining introduction.” —The Economist “Mukherjee has found an especially roomy subject for his roving intelligence. . . . I was repeatedly dazzled by [Mukherjee’s] pointillist scenes, the enthusiasm of his explanations, the immediacy of his metaphors.” —Jennifer Szalai, The New York Times “Mukherjee is such an engaging writer, alert to nanoscopic beauty and the potential deceptions of metaphor. . . . [ The Song of the Cell is] written with compassionate warmth and humor, and the personal glimpses into an ordinary scientific life and the dedication that goes with it.” —Steven Poole, The Telegraph “ The Song of the Cell blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner.” — Oprah Daily Siddhartha Mukherjee is the author of The Gene: An Intimate History, a #1 New York Times bestseller; The Emperor of All Maladies: A Biography of Cancer , winner of the 2011 Pulitzer Prize in general nonfiction; and The Laws of Medicine . He is the editor of Best Science Writing 2013 . Mukherjee is an associate professor of medicine at Columbia University and a cancer physician and researcher. A Rhodes scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. He has published articles in many journals, including Nature , The New England Journal of Medicine , Cell , The New York Times Magazine , and The New Yorker . He lives in New York with his wife and daughters. Visit his website at: SiddharthaMukherjee.com. Read more

Features & Highlights

  • Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences
  • and the 2023 Chautauqua Prize!
  • N
  • amed a
  • New York Times
  • Notable Book and a Best Book of the Year by
  • The Economist
  • ,
  • Oprah Daily, BookPage, Book Riot,
  • the New York Public Library, and more!
  • In
  • The Song of the Cell
  • , the extraordinary author of the Pulitzer Prize–winning
  • The Emperor of All Maladies
  • and the #1
  • New York Times
  • bestseller
  • The Gene
  • “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (
  • Oprah Daily
  • ).
  • Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “
  • cells.
  • ” The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling,
  • The Song of the Cell
  • tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader,
  • The Song of the Cell
  • is both panoramic and intimate—a masterpiece on what it means to be human. “In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (
  • The New Yorker).

Customer Reviews

Rating Breakdown

★★★★★
60%
(1.1K)
★★★★
25%
(457)
★★★
15%
(274)
★★
7%
(128)
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Most Helpful Reviews

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Well researched, well written. But, he misses the most important lessons from cell biology!

He covers a lot of ground and tells some good stories, for this I give him 3 stars. But he really delivers nothing of substance to empower the reader in their own health journey. He basically delivers PR for the current, mostly-failed, overly-reductionistic, money-driven, US Patent-dependent medical paradigm which dominates and drives western society. In short, he proposes that by altering human cells via expensive use of stem cell procedures and expensive gene-altering drugs /procedures, we will make humans 'better' and human life better and less prone to 'certain' diseases. We have all heard this before. Lol! If the reader already has strong faith in our medical system, this book will just reinforce that faith with the same old mantra. Hang on a bit, help is on the way! Lol.

He does correctly make the case that all disease processes/pathologies can be viewed as just cellular dysfunction. In other words, "diseases" (bodily dysfunction) are all essentially the manifestation of cellular dysfunction. This is 100% correct and is important information. But he fails to address two very important things: 1-He makes little mention about WHY these cells become dysfunctional other than saying genetic errors or "we don't know". and 2-He fails to give or even suggest any advice regarding how a regular person might be able to maintain, restore or improve their own cellular function.

We know from evolutionary cell biology that our human cells have undergone very little change in the last 200,000 years. We also know (beyond the shadow of a doubt) that the vast majority of modern-day causes of premature disease/death (CV disease, Cancer and Diabetes/related complications) were virtually non-existent in our genetically-equal ancestors who lived in these preagricultural environments. Conclusion: There is most-likely nothing 'wrong' with most peoples' cells, the malfunctioning cells are just following their genetic blueprint and reacting to the crappy/wrong environment that we have bathed them in! Therefore, medicine, biotech, pharma should all be focusing more on so-called "ancestral medicine" which is basically how to deliver a more genetically-congruent environment to our ancient human cells (via diet, physical activity, mindfulness, etc.). The author makes no mention of this.

Thank you for reading.
48 people found this helpful
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Suddhartha Mukherjee is a modern day Lewis Thomas

Siddhartha Mukherjee is today’s Lewis Thomas. We are blessed to have such a wonderful biological storyteller. He makes complex physiological and medical topics seem so simple to understand. With “Song of the Cell” he takes the reader on a joyful journey of wonder and hope. The book is a tour de force of cellular biology beginning with the earliest discovery of cells and the invention of the microscope. He then explains the different organelles that make up human cells and their functions. The biology of cell division is covered along with how a human body is derived from a single cell. Along the way, each of the body’s major cell types are explored, ranging from cardiac, renal, and neural. I found myself reliving parts of the first two years of medical school as I read. The final sections of the book are dedicated to the marvels of stem cells, and the cancer cell—the selfish cell. Mukherjee goes into some detail about the origins of a cancer cell and potential future cures. Anyone with an interest in learning more about how their body functions and can dysfunction owes it to themselves to read this book. It is worthy of a second Pulitzer for Dr. Mukherjee.
32 people found this helpful
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We are stardust. We are golden.

Having read and enjoyed the authors past two books (The Emperor of all Maladies and The Gene), I eagerly awaited his most recent book, The Song of the Cell. The book doesn’t disappoint. For many of us who studied biology in high school, this book covers a lot of familiar terrain. But this isn’t a textbook. Mukherjee possesses a storyteller’s instinct, and the book moves forward propelled by a cast of characters straight out of a Dicken’s novel.

Staring from the Dutch trader Leeuwenhoek peering into his crude microscope to examine the tiny organisms in drain water to the eccentric German physician Rudolf Virchow who’s free thinking led to the advancement of cellular medicine, the book is replete with amazing scientists whose curiosity and thirst for knowledge has made these wondrous breakthroughs in medicine possible. Reading this book, one realizes how much we take for granted. How complicated the human body is and how magical its operation. Also noteworthy are the thousands of unsung scientists who for years have toiled away (and continue to toil) on lab-benches to enable all the many discoveries that make our present lives so much easier.

Culling stories from his personal and professional life, Mukherjee weaves his tale deftly while explaining complex concepts of cell biology with verve and clarity. The dude clearly loves his subject matter!

My biggest quibble with this book is the lack of clear illustrations. There are some, but they are not particularly helpful. I still can’t figure out where the damn Gremlin cells are located – somewhere in the bones – can you?

Towards the end of the book, Mukherjee touches on Homeostasis, the ability of the human body to reset itself to “factory settings”. This January 2023, the average temperature in New York City has been 10 degrees above normal. The warmest January on record. Our planet is running a fever, and alas mankind has screwed up the planet’s homeostatic functions. I hope for humanity’s sake, there are a band of motivated citizens who help us reset the planet’s systems back to its “factory settings”. Reading “The Song of the Cell” would be a good place to start!
20 people found this helpful
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A prolific scientist provides the history and explanation of cells and their importance.

Author is a doctor, scientist, and Pulitzer Prize winner. This is yet another of his excellent books addressing serious medical/health issues. He explains the medical history of discoveries of the human cells with probably more detail than you wish to read, but it is an enlightening read and an update on serious health issues that have been solved or on the cusp of being solved. This is an excellent read, but not for the faint of heart or those who desire an afternoon read. Take your time and soak up the history and breakthroughs.
10 people found this helpful
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Another Winner

Another outstanding book by SM. His insights are based on both his scientific research work and his clinical experiences treating real patients. His writing is just magnificent; clear, well-informed, and personal. One minor but irritating error needs to be mentioned that should have been caught in coy editing. Page 92 suggests the Mayo Clinic is in Rochester, New York, when it is actually in Rochester, Minnesota.
8 people found this helpful
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Very informative read

I have read Siddhartha Mukherjee's other 2 books and found them fantastic reads. This was no exception. He is a gifted writer, who brings together all the knowledge in the area of cells in a cogent manner. I still found this tougher to read and understand compared to his previous 2 books and had to spend quite some time reading and understanding it. I work as as a biostatistician on immunotherapies and so a lot of this was very relevant and useful to me. I applaud Siddhartha Mukherjee for writing this.
7 people found this helpful
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Looks like something my husband will like.

This will be a Christmas gift for my husband. I'm sure he will like it. We heard the author talk on Amanpour and he was very interesting.
6 people found this helpful
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Simply brilliant

Siddhartha Mukherjee, one of our age’s most brilliant medical writers, is a cancer doctor with research interests in the basic sciences of cell biology and genetics. He is also an engaging writer with a deep knowledge of the history of science. His books, one of which has won a Pulitzer Prize, combine all these crosscurrents to convey a compelling narrative. He’s done it for both genetics and cancer, and here, he hits another home run writing about cell biology.

In this book, he describes the long history of this field and how it has given us more understanding about our bodies’ various facets. He describes how cell biology has impacted various organ systems and translates knowledge of basic science to clinical effects. He also describes patient stories of contemporary impacts of research and cutting-edge research trials that hope to impart new wisdom to the medical establishment.

In this and other works, I’ve read few other authors who can make the history of medicine come alive to the same degree as Mukherjee. His passion for the subject combines many aspects, including stories about scientists’ personal lives, scientific details that have huge impacts on patients (i.e., all of us), and ethical challenges of managing biological innovations.

This book contains a lot of biological knowledge and healthcare experience. Reading about biology is not for the feint of heart. But his prose makes the process enjoyable. Aspiring healthcare workers and biological researchers will benefit from perusing its pages. It can teach a bunch about cell biology while keeping the reader mentally and spiritually engaged. This book provides us with a fun way to learn more about our bodies so that we don’t fall asleep in the process.
4 people found this helpful
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The harmony of cellular biology presented by a master wordsmith

As in his previous books Dr Mukherjee has condensed centuries of highly complex biology into a book that can be appreciated by anyone who reads it. He peppers the book with personal vignettes from his career as a clinician and researcher. His research and knowledge are vast and his engaging style make this book a history of cell biology as well as his previous works on the history of cancer research and genetic research true treasures. Looking forward to more.
4 people found this helpful
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my package was not left at front door it was left on sidewalk

product is fine delivery is not
4 people found this helpful